Role of force - sensitive amyloid - like interactions in fungal 1 catch - bonding and biofilms
نویسندگان
چکیده
Biology Department, City University of New York Brooklyn College and Biochemistry 4 Program, Graduate Center of the City University of New York 5 6 Running Title: Amyloid-dependent fungal catch-binding 7 8 *Corresponding author: 9 Peter Lipke 10 Biology Department, Brooklyn College 11 2900 Bedford Ave. 12 Brooklyn, NY 11210 13 Phone: 718-951-5000 ext. 1949 14 Fax: 718-951-4659 15 e-mail: [email protected] 16 17 18 EC Accepts, published online ahead of print on 28 March 2014 Eukaryotic Cell doi:10.1128/EC.00068-14 Copyright © 2014, American Society for Microbiology. All Rights Reserved.
منابع مشابه
Role of force-sensitive amyloid-like interactions in fungal catch bonding and biofilms.
The Candida albicans Als adhesin Als5p has an amyloid-forming sequence that is required for aggregation and formation of model biofilms on polystyrene. Because amyloid formation can be triggered by force, we investigated whether laminar flow could activate amyloid formation and increase binding to surfaces. Shearing Saccharomyces cerevisiae cells expressing Als5p or C. albicans at 0.8 dyne/cm(2...
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